Cannabis & Strokes


Stroke

Title: US Patent 6630507: Cannabinoids As Antioxidants And Neuroprotectants

Key Findings

“Cannabinoids neuroprotective in stroke.”

Information & Links

Link: US Patent 6630507: Cannabinoids As Antioxidants And Neuroprotectants

Year: 2003

Source: https://patents.google.com/patent/US6630507  

---


Title: Cannabidiol Attenuates OGD/R-induced Damage By Enhancing Mitochondrial Bioenergetics And Modulating Glucose Metabolism Via Pentose-phosphate Pathway In Hippocampal Neurons

Key Findings

“Cannabidiol protects hippocampal neurons from oxygen–glucose-deprivation/reperfusion-induced oxidative stress. Cannabidiol enhances mitochondrial bioenergetics. Cannabidiol optimizes glucose metabolism via the pentose-phosphate pathway. CBD is neuro-protective.”

Information & Links

Link: Cannabidiol Attenuates OGD/R-induced Damage By Enhancing Mitochondrial Bioenergetics And Modulating Glucose Metabolism Via Pentose-phosphate Pathway In Hippocampal Neurons

Year: 2017

DOI: http://dx.doi.org/10.1016/j.redox.2016.12.029

---


Title: Anti-excitotoxic Effects Of Cannabidiol Are Partly Mediated By Enhancement Of NCX2 And NCX3 Expression In Animal Model Of Cerebral Ischemia

Key Findings

“These findings support the view that the reduction of ischemic injuries elicited by cannabidiol can be at least partly due to the enhancement of NCX protein expression and its cerebro-protective role in those cerebral territories supplied by the middle cerebral artery.”

Information & Links

Link: Anti-excitotoxic Effects Of Cannabidiol Are Partly Mediated By Enhancement Of NCX2 And NCX3 Expression In Animal Model Of Cerebral Ischemia

Year: 2017

DOI: 10.1016/j.ejphar.2016.11.011

---


Title: Prior Cannabis Use Is Associated With Outcome After Intracerebral Hemorrhage

Key Findings

“Cannabinoid+ patients had milder stroke presentation and less disability at discharge.”

Information & Links

Link: Prior Cannabis Use Is Associated With Outcome After Intracerebral Hemorrhage

Year: 2016

DOI: 10.1159/000443532

---


Title: Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia

Key Findings

“Short-term CBD 10mg/kg treatment prevented the cognitive and emotional impairments and attenuated hippocampal neurodegeneration and white matter injury. CBD also stimulated neurogenesis and promoted dendritic restructuring in the hippocampus of the test animals. Collectively, the present results demonstrate that short-term CBD treatment results in global functional recovery in ischemic mice and impacts multiple and distinct targets involved in the pathophysiology of brain ischemic injury.”

Information & Links

Link: Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia.

Year: 2016

DOI: 10.1016/j.pnpbp.2016.11.005

---


Title: Cannabinoid Type-2 Receptor Drives Neurogenesis And Improves Functional Outcome After Stroke

Key Findings

“Our data support that CB2R is fundamental for driving neuroblast migration and suggest that an endocannabinoid tone is required for poststroke neurogenesis by promoting neuroblast migration toward the injured brain tissue, increasing the number of new cortical neurons and, conceivably, enhancing motor functional recovery after stroke.”

Information & Links

Link: Cannabinoid Type-2 Receptor Drives Neurogenesis And Improves Functional Outcome After Stroke

Year: 2016

DOI: 10.1161/STROKEAHA.116.014793

---


Title: Cannabidiol Reduces Brain Damage And Improves Functional Recovery In A Neonatal Rat Model Of Arterial Ischemic Stroke

Key Findings

“CBD administration after Middle Cerebral Artery Occlusion (MCAO) led to long-term functional recovery, reducing neuronal loss and astrogliosis, and modulating apoptosis, metabolic derangement, excitotoxicity and neuro-inflammation.”

Information & Links

Link: Cannabidiol Reduces Brain Damage And Improves Functional Recovery In A Neonatal Rat Model Of Arterial Ischemic Stroke

Year: 2016

DOI: 10.1016/j.neuropharm.2016.12.017

---


Title: Protective Effects Of Cannabidiol Against Hippocampal Cell Death And Cognitive Impairment Induced By Bilateral Common Carotid Artery Occlusion In Mice

Key Findings

“These findings suggest a protective effect of CBD on neuronal death induced by ischemia and indicate that CBD might exert beneficial therapeutic effects in brain ischemia.”

Information & Links

Link: Protective Effects Of Cannabidiol Against Hippocampal Cell Death And Cognitive Impairment Induced By Bilateral Common Carotid Artery Occlusion In Mice

Year: 2014

DOI: 10.1007/s12640-014-9457-0

---


Title: Endocannabinoids and the cardiovascular response to stress

Key Findings

“Stress activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS), resulting in cardiovascular responses. The endocannabinoid system (ECS), a ubiquitously expressed lipid signalling system, modulates both HPA and SNS activity. The ECS has numerous cardiovascular effects including modulation of blood pressure, heart rate, the baroreflex, and direct vascular actions. It is also involved in a protective manner in response to stressors in cardiac preconditioning, and various stressors (for example, pain, orthostasis and social stress) increase plasma levels of endocannabinoids.”

Information & Links

Link: Endocannabinoids and the cardiovascular response to stress.

Year: 2012

DOI: 10.1177/0269881111408457

---


Leave a comment


Please note, comments must be approved before they are published