Cannabis & Stress


Stress

Title: FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence

Key Findings

“A common single nucleotide polymorphism (C385A) in the human fatty acid amide hydrolase (FAAH) gene has been associated with decreased distress responses in healthy volunteers. Here, we obtained genotypes and carried out a secondary analysis of subjects from a trial of comorbid posttraumatic stress disorder (PTSD) and alcohol dependence (AD). This is to our knowledge the first study showing that FAAH C385A variation modulates stress responses in subjects with disorders characterized by increased stress reactivity. These findings point to the eCB pathway as a promising target for future antistress therapeutics.”

Information & Links

Link: FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence

Year: 2016

DOI: 10.1111/acer.13210

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Title:  Blunted Stress Reactivity In Chronic Cannabis Users

Key Findings

“Subjective stress ratings and cortisol levels were significantly higher in non-users in the stress condition relative to non-users in the no stress condition.”

Information & Links

Link: Blunted Stress Reactivity In Chronic Cannabis Users

Year: 2017

DOI: 10.1007/s00213-017-4648-z

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Title: Variants In The CNR1 Gene Predispose To Headache With Nausea In The Presence Of Life Stress

Key Findings

“One of the main effects of the endocannabinoid system in the brain is stress adaptation with presynaptic endocannabinoid receptor 1 (CB1 receptors) playing a major role. In summary, the CNR1 gene in interaction with life stress increased the risk of headache with nausea suggesting a specific pathological mechanism to develop migraine, and indicating that a subgroup of migraine patients, who suffer from life stress triggered migraine with frequent nausea, may benefit from therapies that increase the endocannabinoid tone.”

Information & Links

Link: Variants In The CNR1 Gene Predispose To Headache With Nausea In The Presence Of Life Stress

Year: 2016

DOI: 10.1111/gbb.12352

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Title: FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence

Key Findings

“A common single nucleotide polymorphism (C385A) in the human fatty acid amide hydrolase (FAAH) gene has been associated with decreased distress responses in healthy volunteers. Here, we obtained genotypes and carried out a secondary analysis of subjects from a trial of comorbid posttraumatic stress disorder (PTSD) and alcohol dependence (AD). This is to our knowledge the first study showing that FAAH C385A variation modulates stress responses in subjects with disorders characterized by increased stress reactivity. These findings point to the eCB pathway as a promising target for future antistress therapeutics.”

Information & Links

Link: FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence

Year: 2016

DOI: 10.1111/acer.13210

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Title: FAAH Genetic Variation Enhances Fronto-amygdala Function In Mouse And Human

Key Findings

“These results suggest a gain-of-function in fear regulation and may indicate for whom and for what anxiety symptoms FAAH inhibitors or exposure-based therapies will be most efficacious, bridging an important translational gap between the mouse and human.”

Information & Links

Link: FAAH Genetic Variation Enhances Fronto-amygdala Function In Mouse And Human

Year: 2015

DOI: 10.1038/ncomms7395

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Title: Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology.

Key Findings

“Δ-9-THC and CBD had opposite effects on activation relative to placebo in the striatum during verbal recall, in the hippocampus during the response inhibition task, in the amygdala when subjects viewed fearful faces, in the superior temporal cortex when subjects listened to speech, and in the occipital cortex during visual processing. In the second experiment, pretreatment with CBD prevented the acute induction of psychotic symptoms by Δ-9-tetrahydrocannabinol. Δ-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Δ-9-THC.”

Information & Links

Link: Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology.

Year: 2010

DOI: 10.1038/npp.2009.184

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