Cannabis & PTSD


PTSD

Title: Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report

Key Findings

Anxiety and sleep disorders are often the result of posttraumatic stress disorder and can contribute to an impaired ability to focus and to demonstration of oppositional behaviors.” … “Cannabidiol oil, an increasingly popular treatment of anxiety and sleep issues, has been documented as being an effective alternative to pharmaceutical medications. This case study provides clinical data that support the use of cannabidiol oil as a safe treatment for reducing anxiety and improving sleep in a young girl with posttraumatic stress disorder.”

Information & Links

Year: 2016

DOI: 10.7812/TPP/16-005

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101100/

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Title: Psychobiological Responses To Aerobic Exercise In Individuals With Posttraumatic Stress Disorder

Key Findings

"Improvements in mood, reduction in pain, correlated with increases in endocannabinoids (circulating concentrations of N-arachidonylethanolamine (AEA), 2-arachidonoylglycerol (2-AG), and oleoylethanolamide (OEA) significantly increased following the aerobic exercise session for both groups)."

Information & Links

Link: Psychobiological Responses To Aerobic Exercise In Individuals With Posttraumatic Stress Disorder

Year: 2018

DOI: 10.1002/jts.22253

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Title: FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence

Key Findings:

"A common single nucleotide polymorphism (C385A) in the human fatty acid amide hydrolase (FAAH) gene has been associated with decreased distress responses in healthy volunteers. Here, we obtained genotypes and carried out a secondary analysis of subjects from a trial of comorbid posttraumatic stress disorder (PTSD) and alcohol dependence (AD). This is to our knowledge the first study showing that FAAH C385A variation modulates stress responses in subjects with disorders characterized by increased stress reactivity. These findings point to the eCB pathway as a promising target for future antistress therapeutics."

Information & Links

Link: FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence

Year: 2016

DOI: 10.1111/acer.13210

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Title: The Efficacy Of Nabilone, A Synthetic Cannabinoid, In The Treatment Of PTSD-associated Nightmares: A Preliminary Randomized, Double-blind, Placebo-controlled Cross-over Design Study

Key Findings

"In this small sample NAB provided significant relief for military personnel with PTSD, indicating that it shows promise as a clinically-relevant treatment for patients with nightmares and a history of non-response to traditional therapies."

Information & Links

Link: The Efficacy Of Nabilone, A Synthetic Cannabinoid, In The Treatment Of PTSD-associated Nightmares: A Preliminary Randomized, Double-blind, Placebo-controlled Cross-over Design Study

Year: 2015

DOI: 10.1016/j.psyneuen.2014.11.002

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Title: Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks

Key Findings

"This report shows that PTSD is associated with a reduction in circulating levels of the ECB 2-AG. There were no significant group differences for AEA or cortisol levels; however, across the whole sample AEA levels positively correlated with circulating cortisol, and AEA levels exhibited a negative relationship with the degree of intrusive symptoms within the PTSD sample. The negative association between AEA levels and intrusive symptoms is consistent with animal data indicating that reductions in AEA promote retention of aversive emotional memories."

Information & Links

Link: Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks.

Year: 2013

DOI: 10.1016/j.psyneuen.2013.08.004

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