Cannabis & Anxiety


Anxiety

Title: Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.

Key Findings

“Generalized Social Anxiety Disorder (SAD) is one of the most common anxiety conditions with impairment in social life. Cannabidiol (CBD), one major non-psychotomimetic compound of the cannabis sativa plant, has shown anxiolytic effects both in humans and in animals. This preliminary study aimed to compare the effects of a simulation public speaking test (SPST) on healthy control (HC) patients and treatment-naïve SAD patients who received a single dose of CBD or placebo. Pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech. The placebo group presented higher anxiety, cognitive impairment, discomfort, and alert levels when compared with the control group as assessed with the VAMS. The SSPS-N scores evidenced significant increases during the testing of placebo group that was almost abolished in the CBD group. No significant differences were observed between CBD and HC in SSPS-N scores or in the cognitive impairment, discomfort, and alert factors of VAMS. The increase in anxiety induced by the SPST on subjects with SAD was reduced with the use of CBD, resulting in a similar response as the HC.”

Information & Links

Link: https://www.ncbi.nlm.nih.gov/pubmed/21307846

Year: 2011

DOI: 10.1038/npp.2011.6

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Title: Cannabidiol as a Potential Treatment for Anxiety Disorders

Key Findings

“Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders. The purpose of the current review is to determine CBD’s potential as a treatment for anxiety-related disorders, by assessing evidence from preclinical, human experimental, clinical, and epidemiological studies. We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive–compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing. Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations.”

Information & Links

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/

Year: 2015

DOI: 10.1007/s13311-015-0387-1

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Title: Cannabidiol Does Not Dampen Responses To Emotional Stimuli In Healthy Adults

Key Findings

“The study used a double-blind, placebo (PLB)-controlled, within-subjects design in which 38 healthy, drug-free participants consumed oral CBD (300, 600, and 900 mg) or PLB before completing several behavioral tasks selected to assess reactivity to negative stimuli.”

Information & Links

Link: Cannabidiol Does Not Dampen Responses To Emotional Stimuli In Healthy Adults

Year: 2017

DOI: 10.1089/can.2017.001

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Title: Cannabidiol Enhances Consolidation Of Explicit Fear Extinction In Humans

Key Findings

“These findings provide the first evidence that CBD can enhance consolidation of extinction learning in humans and suggest that CBD may have potential as an adjunct to extinction-based therapies for anxiety disorders.”

Information & Links

Link: Cannabidiol Enhances Consolidation Of Explicit Fear Extinction In Humans

Year: 2013

DOI: 10.1007/s00213-012-2955-y

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Title: Cannabidiol Reduces The Anxiety Induced By Simulated Public Speaking In Treatment-Naïve Social Phobia Patients

Key Findings

“Pretreatment with CBD was able to significantly reduced anxiety, cognitive impairment, and discomfort in their speech performance.”

Information & Links

Link: Cannabidiol Reduces The Anxiety Induced By Simulated Public Speaking In Treatment-Naïve Social Phobia Patients

Year: 2011

DOI: 10.1038/npp.2011.6

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Title: Neural Basis Of Anxiolytic Effects Of Cannabidiol (CBD) In Generalized Social Anxiety Disorder: A Preliminary Report

Key Findings

“CBD was associated with significantly decreased subjective anxiety (p < 0.001), reduced ECD uptake in the left parahippocampal gyrus, hippocampus, and inferior temporal gyrus (p < 0.001, uncorrected), and increased ECD uptake in the right posterior cingulate gyrus (p < 0.001, uncorrected). These results suggest that CBD reduces anxiety in SAD and that this is related to its effects on activity in limbic and paralimbic brain areas.”

Information & Links

Link: Neural Basis Of Anxiolytic Effects Of Cannabidiol (CBD) In Generalized Social Anxiety Disorder: A Preliminary Report

Year: 2011

DOI: 10.1177/0269881110379283

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Title: Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology.

Key Findings

“Δ-9-THC and CBD had opposite effects on activation relative to placebo in the striatum during verbal recall, in the hippocampus during the response inhibition task, in the amygdala when subjects viewed fearful faces, in the superior temporal cortex when subjects listened to speech, and in the occipital cortex during visual processing. In the second experiment, pretreatment with CBD prevented the acute induction of psychotic symptoms by Δ-9-tetrahydrocannabinol. Δ-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Δ-9-THC.”

Information & Links

Link: Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology.

Year: 2010

DOI: 10.1038/npp.2009.184

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Title: FAAH Genetic Variation Enhances Fronto-amygdala Function In Mouse And Human

Key Findings

“These results suggest a gain-of-function in fear regulation and may indicate for whom and for what anxiety symptoms FAAH inhibitors or exposure-based therapies will be most efficacious, bridging an important translational gap between the mouse and human.”

Information & Links

Link: FAAH Genetic Variation Enhances Fronto-amygdala Function In Mouse And Human

Year: 2015

DOI: 10.1038/ncomms7395

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