Cannabis & Addiction


Addiction


Title: Nabiximols Combined With Motivational Enhancement/cognitive Behavioral Therapy For The Treatment Of Cannabis Dependence: A Pilot Randomized Clinical Trial

Key Findings

“Nabiximols in combination with Motivational Enhancement Therapy and Cognitive Behavioral Therapy was well tolerated and allowed for reduction of cannabis use. Future clinical trials should explore the potential of high doses of nabiximols for cannabis dependence.”

Information & Links

Link: Nabiximols Combined With Motivational Enhancement/cognitive Behavioral Therapy For The Treatment Of Cannabis Dependence: A Pilot Randomized Clinical Trial.

Year: 2018

DOI: 10.1371/journal.pone.0190768

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Title: Comparative Epidemiology Of Dependence On Tobacco, Alcohol, Controlled Substances, And Inhalants: Basic Findings From The National Comorbidity Survey

Key Findings

“A large-scale survey conducted across the U.S. on more than eight thousand people ages fifteen to fifty-four described possible drug dependence patterns as follows: most prevalent was cigarettes, next was heroin. Cocaine and alcohol followed, and cannabis ranked among the lowest.”

Information & Links

Link: Comparative Epidemiology Of Dependence On Tobacco, Alcohol, Controlled Substances, And Inhalants: Basic Findings From The National Comorbidity Survey.

Year: 1994

DOI: http://dx.doi.org/10.1037/1064-1297.2.3.244

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Title: Book Title: The Chemistry Of Mind-Altering Drugs: History, Pharmacology, And Cultural Context

Key Findings

“Perrine's results showed the most addictive drug to be nicotine, followed by alcohol, heroin, cocaine, caffeine, and lastly cannabis.”

Information & Links

Link: Book Title: The Chemistry Of Mind-Altering Drugs: History, Pharmacology, And Cultural Context.

Year: 1999

DOI: https://doi.org/10.1176/ajp.156.1.154a.

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Title: Impact Of Co-administration Of Oxycodone And Smoked Cannabis On Analgesia And Abuse Liability

Key Findings

“Cannabis enhances the analgesic effects of sub-threshold oxycodone, suggesting synergy, without increases in cannabis's abuse liability. These findings support future research into the therapeutic use of opioid-cannabinoid combinations for pain.”

Information & Links

Link: Impact Of Co-administration Of Oxycodone And Smoked Cannabis On Analgesia And Abuse Liability

Year: 2018

DOI: 10.1038/s41386-018-0011-2

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Title: FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence

Key Findings

A common single nucleotide polymorphism (C385A) in the human fatty acid amide hydrolase (FAAH) gene has been associated with decreased distress responses in healthy volunteers. Here, we obtained genotypes and carried out a secondary analysis of subjects from a trial of comorbid posttraumatic stress disorder (PTSD) and alcohol dependence (AD). This is to our knowledge the first study showing that FAAH C385A variation modulates stress responses in subjects with disorders characterized by increased stress reactivity. These findings point to the eCB pathway as a promising target for future antistress therapeutics.

Information & Links

Link: FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence

Year: 2016

DOI: 10.1111/acer.13210

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